The Turd Nerds podcast, discuss constipation drugs. They provide definitions and data on drugs for irritable bowel syndrome constipation (IBSC) and chronic idiopathic constipation. They cover various categories of drugs, including over-the-counter laxatives, antidepressants, secretagogues, prokinetics, opioid receptor agonists, dopamine antagonists, macrolide antibiotics, and probiotics. They also discuss the importance of fiber and water intake in managing constipation. The hosts share their experiences and insights on the efficacy and side effects of different drugs. In this conversation, the hosts discuss different classes of drugs used for constipation treatment. They cover secretagogues, prokinetics, macrolide antibiotics, dopamine antagonists, and probiotics. They highlight the efficacy and side effects of each class and provide clinical pearls. The hosts also emphasize the importance of lifestyle and diet modifications as the first line of treatment. They conclude by summarizing the key takeaways and encouraging listeners to subscribe and rate the podcast.