The Turd investigate atonic constipation and drug-induced constipation. They discuss various drugs that contribute to constipation, such as opiates, anticholinergics, and diuretics. The hosts explain the causes and symptoms of atonic constipation, marked by a lazy colon and baggy rectum, and highlight the importance of reviewing patients' medication and supplement lists to ensure accurate diagnosis and treatment. They also touch on the benefits of prokinetics and herbal remedies for managing constipation.