Part 2 or our 3 part serires on Prokinetics. In this episode we look at different classes of drugs that can help with constipation. They start by talking about acetylcholine esterase inhibitors, which increase the activity of acetylcholine in the gut and improve colonic motility. They then move on to macrolides, which are antibiotics that also have prokinetic effects. Finally, they discuss opioid antagonists and peripherally acting mu-opioid receptor agonists, which are used to treat opioid-induced constipation. Overall, these drugs can help improve bowel movements and relieve constipation in different patient populations.