In this episode, Drs. Sand, Kapadia, and Gurevich provide a comprehensive overview of intestinal permeability, exploring its causes and the impact of diet and lifestyle on this complex condition. They delve into the challenges of defining the intestinal barrier and the various testing methods available, including lactulose-mannitol testing, Zonulin, LPS, and anti-vinculin and anti-CDTB tests. The discussion also covers potential treatment options such as glutamine, resveratrol, quercetin, and zinc carnosine, and debates the role of probiotics in healing the intestinal lining. Additionally, they address the importance of monitoring zinc and copper blood values in managing intestinal permeability.