In this episode, the Turd Nerds discuss the potential link between atopic disease and irritable bowel syndrome (IBS). They explore the concept of atopic bowel, where there is irritation of the gut due to inhalant or food sensitivities. The hosts review several studies that show a correlation between atopic disease, food sensitivities, and GI symptoms. They also discuss the role of intestinal permeability and genetic factors in the development of both atopic disease and IBS. The episode concludes with a discussion on the workup and potential treatments for patients with atopic bowel.