In this episode, the Turd Nerds discuss small intestinal fungal overgrowth (SIFO) and its similarities to SIBO. They explain that SIFO is an excessive number of fungal organisms in the small intestine, which can cause symptoms such as gas, bloating, diarrhea, and constipation. They also mention that SIFO can be associated with other conditions like histamine issues and mast cell activation syndrome (MCAS). The Turd Nerds discuss the challenges of diagnosing SIFO and the different testing options available. They also talk about the treatment approach for SIFO, which may involve addressing protozoa first and then focusing on bacterial and fungal overgrowth. They emphasize the importance of considering SIFO in patients with chronic digestive issues and potential MCAS.